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KMID : 0380319910470000121
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Journal of Korean Research Institute for Better Living
1991 Volume.47 No. 0 p.121 ~ p.130
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The Changes of the Disribution of Nerve Cells in Cerebral Cortex of Carbon Monoxide-induced Hypoxic Mice
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Abstract
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We studied the changes of the distribution on nerve cells in cerebral cortex of hypoxic mice induced by carbon monoxide(CO).
When the mice exposed to 5,000 ppm CO for 60 minutes, carboxyhemoglobin level was 82％. At zero, 1st, 3rd, 5th, 7th and 14th day after CO intoxication, hypoxic and normal mice were fixed by 3.5％ formalin and each of motor(area 4), somatosensory(area 3) and visual(area 17) cortices of the cerebral cortex, was sectioned and stained with cresyl violet. Using light microscope quantitative analysis was followed.
Our results could be summarized as follows : The insignificant and significant decreases in number of nerve cells, were observed in the motor and somatosensory cortices, at zero, 1st day and at 3rd, 5th, 7th, 14th day after CO intoxication respectively. The same mode of decreases in the number of nerve cells was also observed in the visual cortex, at zero and at 1st, 3rd, 5th, 7th, 14th day after CO intoxication respectively. A series of decreasing phenomena in the above results were more evident in visual cortex than motor and somatosensory cortices.
It may be concluded from these findings that the decrease of nerve cells in the mice exposed to CO causes the damage of nerve cell in the cerebral cortex and it is connected with necrosis.
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